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Creatinine clearance at menopause is not related to bone mass in later life
C Hassager1, Q Wang, C Christiansen
1Center for Clinical & Basic Research, Ballerup, Denmark.
Objective:
To investigate whether creatinine clearance (Ccr) at menopause is related to bone mass later in life.
Methods:
Ccr was measured within 5 years after natural menopause in two groups of normal women. Bone mineral content (BMC) of the distal forearm, lumbar spine, and proximal femur were measured by photon absorptiometry and dual energy X-ray absorptiometry in these women 6 years (n = 47) and 14 years later (n = 98).
Results:
Ccr corrected for body surface area just after the menopause did not correlate with BMC, 6.5 years and 14.5 years later.
Conclusion:
Low Ccr within the normal range at menopause is not an independent risk factor for osteopenia in later life.