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Aged rats are still responsive to the antidepressant and memory-improving effects of oxytocin
R Arletti1, A Benelli, R Poggioli
1Department of Biomedical Sciences, University of Modena, Italy.
Neuropeptides
|September 1, 1995
Abstract:
Oxytocin, intraperitoneally injected to 26-month-old male rats 60 min before testing, significantly improved social memory (at doses of 3 and 6 ng/kg) and reduced the duration of immobility in the behavioral despair test (at doses of 50 and 500 micrograms/kg). These results are in agreement with previous data obtained in adult rats and indicate that aging does not compromise the social memory improving and antidepressant-like activities of oxytocin.