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Influence of 17 beta-estradiol and progesterone on rat ocular lens
J Scharf1, N Azzam, D Schapira
1Department of Ophthalmology, Rambam Medical Center, Haifa, Israel.
Ophthalmic Research
|January 1, 1995
Abstract:
The effect of 17 beta-estradiol and progesterone on ocular lens in rats and untreated controls was studied. In the treated lenses, the activity of hexokinase and glucose-6-phosphate dehydrogenase remained unchanged. The activity of aldolase was increased in 18- and 20-month-old lenses as compared to controls. Aldose reductase activity was decreased at the age of 20 months (p < 0.001). Structural lens proteins studies by SDS polyacrylamide gel electrophoresis and immunodecoration with specific antibodies for crystallines alpha A + alpha B and beta + gamma suggest some protective effect in treated animals.