Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Ondansetron improves cognitive performance in the Morris water maze spatial navigation task

D J Fontana1, S E Daniels, C Henderson

  • 1Department of Neurosciences, Syntex Discovery Research, Palo Alto, CA 94304, USA.

Psychopharmacology
|August 1, 1995
PubMed
Summary

Ondansetron, a 5-HT3 receptor antagonist, improved spatial memory in rats with induced cognitive deficits and in aged, impaired rats. This suggests potential cognition-enhancing effects in models of aging and cholinergic hypofunction.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Measurements of <math></math> production cross sections and constraints on anomalous triple gauge couplings at <math> </math>.

The European physical journal. C, Particles and fields·2021
Same author

Search for dark matter produced in association with a leptonically decaying <math></math> boson in proton-proton collisions at <math> </math>.

The European physical journal. C, Particles and fields·2021
Same author

Search for top squark pair production using dilepton final states in <math></math> collision data collected at <math> </math>.

The European physical journal. C, Particles and fields·2021
Same author

Mental health and caregiving experiences of family carers supporting people with psychosis.

Epidemiology and psychiatric sciences·2021
Same author

Measurement of single-diffractive dijet production in proton-proton collisions at <math> </math> with the CMS and TOTEM experiments.

The European physical journal. C, Particles and fields·2020
Same author

Evidence for Top Quark Production in Nucleus-Nucleus Collisions.

Physical review letters·2020

Area of Science:

  • Neuroscience
  • Pharmacology

Background:

  • Cognitive deficits are associated with aging and cholinergic hypofunction.
  • 5-hydroxytryptamine3 (5-HT3) receptor antagonists are investigated for their therapeutic potential.

Purpose of the Study:

  • To investigate the effects of ondansetron on spatial navigation and memory in rat models.
  • To compare ondansetron's efficacy with physostigmine in attenuating cognitive deficits.

Main Methods:

  • Utilized the Morris water maze task to assess spatial learning and memory in rats.
  • Induced cognitive deficits using atropine (muscarinic antagonist) and tested aged rats.
  • Administered ondansetron and physostigmine and measured latency to find a submerged platform.

Main Results:

Related Experiment Videos

  • Both ondansetron and physostigmine reduced latencies in atropine-treated rats, indicating improved cognitive performance.
  • Ondansetron (0.1 mg/kg) improved performance in aged, cognition-impaired rats, while physostigmine did not.
  • Higher doses of ondansetron (3 mg/kg) showed reduced efficacy.

Conclusions:

  • Ondansetron demonstrates cognition-enhancing properties in animal models relevant to aging and cholinergic hypofunction.
  • Ondansetron may offer a therapeutic strategy for cognitive impairments associated with these conditions.