Related Experiment Videos
Amphetamine analogs have differential effects on DRL 36-s schedule performance
K E Sabol1, J B Richards, K Layton
1University of Chicago, Department of Pharmacological and Physiological Sciences, IL 60637, USA.
Psychopharmacology
|September 1, 1995
Summary
Five amphetamine analogs differentially affect behavior on a DRL 36-s schedule. Dopamine and serotonin release correlate with observed behavioral changes, indicating distinct roles in task mediation.
Area of Science:
- Neuroscience
- Psychopharmacology
- Behavioral Pharmacology
Background:
- Amphetamine analogs are known to differentially affect dopamine (DA) and serotonin (5HT) release.
- Understanding these differential effects is crucial for elucidating neurotransmitter roles in complex behaviors.
Purpose of the Study:
- To compare the effects of five amphetamine analogs on differential reinforcement of low rate 36-s (DRL 36-s) schedule performance.
- To correlate in vivo neurotransmitter release with observed behavioral changes induced by these compounds.
Main Methods:
- Utilized a DRL 36-s schedule to assess behavioral performance.
- Administered five amphetamine analogs: amphetamine (AMPH), methamphetamine (METH), methylenedioxymethamphetamine (MDMA), para-chloroamphetamine (PCA), and fenfluramine (FEN).
- Analyzed response rates, reinforcement rates, inter-response time (IRT) distributions, and schedule control.
Main Results:
- AMPH and METH significantly increased response rates, while MDMA and PCA caused smaller increases; FEN had no effect.
- AMPH, METH, PCA, and MDMA decreased reinforcement rates, with FEN showing no effect.
- All drugs decreased schedule control, evidenced by a dose-dependent decrease in peak area of the IRT distribution.
Conclusions:
- Behavioral effects align with known DA and 5HT release profiles.
- Suggests a predominant dopamine role for AMPH and METH.
- Indicates a predominant serotonin role for FEN, and combined roles for MDMA and PCA in mediating DRL 36-s performance.