Studies on the synthesis of dehydroepiandrosterone (DHEA) phosphatide
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Updated: Oct 31, 2026

Real-time Monitoring of Ligand-receptor Interactions with Fluorescence Resonance Energy Transfer
Published on: August 20, 2012
1Department of Chemistry, Temple University, Philadelphia, Pennsylvania 19122-2585, USA.
Abstract:
Synthetic dehydroepiandrosterone (DHEA) phosphatide 1c, (R = C15H31), was prepared by three methods. The most efficient of these involved the coupling of the commercially available DHEA 1a and commercially available phosphatidic acid 2, via mesitylene sulfonyl chloride and pyridine. Alternatively, DHEA-3-phosphate 1b was coupled with dipalmitoyl glycerol 3 in the same way. The third synthesis gave 1c by coupling DHEA with the cyclic phosphotriester 4 followed by deblocking.
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