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Related Experiment Videos

Superior temporal gyrus volume in schizophrenia: a study using MRI morphometry assisted by surface rendering

J J Kulynych1, K Vladar, D W Jones

  • 1Clinical Brain Disorders Branch, NIMH, NIH, Washington, DC, USA.

The American Journal of Psychiatry
|January 1, 1996
PubMed
Summary

This study found no significant reduction in superior temporal gyrus volume in schizophrenia patients, highlighting the impact of methodological variations in MRI scans for neuroimaging research.

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Area of Science:

  • Neuroimaging
  • Neuroscience
  • Psychiatry

Background:

  • Schizophrenia research often examines brain structure, with the superior temporal gyrus (STG) volume being a key area of interest.
  • Previous studies on STG volume in schizophrenia have yielded inconsistent results, potentially due to methodological differences and challenges in defining gyral boundaries.

Purpose of the Study:

  • To develop and apply a novel 3D morphometric technique incorporating cortical surface information to assess STG volume in schizophrenia.
  • To compare this new method with traditional slice-based approaches and investigate STG laterality in patients and controls.

Main Methods:

  • A 3D morphometric approach using cortical renderings was developed to define STG boundaries more accurately.
  • STG volume was assessed in young, right-handed male patients with schizophrenia and matched control subjects.

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  • The novel technique was compared against slice-based methods using established subcortical landmarks.

    • Main Results:

    • No significant difference in STG volume was found between patients with schizophrenia and comparison subjects.
    • Significant leftward STG laterality was observed only in the control group, not in patients.
    • The slice-based method failed to detect leftward laterality, suggesting it may omit significant STG tissue.

    Conclusions:

    • The study did not confirm a significant reduction in STG volume in this cohort of schizophrenia patients, possibly due to small effect sizes.
    • Methodological variations in MRI analysis significantly influence the measurement of STG volume.
    • The developed 3D morphometric technique offers a potentially more accurate method for assessing brain structures like the STG.