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Updated: Oct 7, 2026

Direct Drug Delivery to Kidney via the Renal Artery
Published on: April 17, 2021
Hypertensive urgency due to cholesterol embolization of kidneys
1Department of Medicine, VA Medical Center, Minneapolis, Minnesota 55417, USA.
Insights
Cholesterol embolization syndrome can cause severe hypertension following carotid endarterectomy. Diagnosis involves identifying aortic atheromata and plaque emboli via transesophageal echocardiography.
Area of Science:
- Cardiovascular Medicine
- Nephrology
- Vascular Surgery
Background:
- Carotid endarterectomy is a common procedure to prevent stroke.
- Complications, though rare, can arise from atherosclerotic plaque manipulation.
Observation:
- A 65-year-old male presented with severe, acute hypertension four weeks post-left carotid endarterectomy.
- The hypertension was attributed to cholesterol embolization affecting the kidneys.
Findings:
- Mobile, protruding atheromata were identified in the descending thoracic aorta.
- Transesophageal echocardiography visualized distal embolization of a plaque fragment, confirming the diagnosis.
Implications:
- This case highlights a potential cause of post-procedural hypertension.
- Early diagnosis via advanced imaging is crucial for managing cholesterol embolization syndrome.
- Understanding embolic risks informs surgical and post-operative care strategies.
Abstract:
Four weeks after left carotid endarterectomy, a 65-year-old man developed severe, acute hypertension due to cholesterol embolization of the kidneys. The diagnosis was established by the demonstration of mobile, protruding atheromata in the descending thoracic aorta and the visualization of distal embolization of a plaque fragment by transesophageal echocardiography.
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