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Cloning and expression of human cDNA encoding phosphatidylinositol transfer protein beta
S Tanaka1, S Yamashita, K Hosaka
1Department of Biochemistry, Gunma University School of Medicine, Maebashi, Japan.
Biochimica Et Biophysica Acta
|December 7, 1995
Abstract:
cDNA encoding the beta isoform of human phosphatidylinositol transfer protein was cloned from a human brain cDNA library. The deduced sequence of the protein comprised 271 amino acids with a calculated molecular mass of 31,539 Da, and showed 98.1% identity to that of the beta isoform of rat phosphatidylinositol transfer protein. The cDNA hybridized to a 3.4-kb mRNA, which was widely expressed in various human tissues including brain.