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Revised European-American Lymphoma Classification

S A Pileri¹, L Leoncini, B Falini

¹Second Service of Pathologic Anatomy-Haematopathology Unit, Bologna University, S. Orsola Hospital, Italy.

Current Opinion in Oncology

|September 1, 1995

Summary

The Revised European-American Lymphoma Classification offers a unified approach to lymphoid tumors, integrating diverse data for improved diagnosis. This updated classification addresses long-standing controversies in hematopathology.

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Area of Science:

Hematopathology
Oncology
Lymphoid Neoplasms

Background:

Lymphoma classification has faced decades of controversy among pathologists and clinicians.
Previous classification schemes lacked comprehensive integration of various lymphoid tumor types.

Purpose of the Study:

To present the Revised European-American Lymphoma Classification (REAL) as a consensus-driven solution.
To highlight the advantages of the REAL classification over prior systems.

Main Methods:

Formulation by 19 experienced hematopathologists.
Agreement on a standardized list of clinicopathologic entities.
Inclusion of nodal and extranodal lymphoid tumors, including Hodgkin's disease.

Main Results:

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The REAL classification incorporates all lymphoid tumors, updating histogenetic understanding.
It recognizes new categories like mantle cell lymphoma and groups entities needing further validation.
Morphologic grading is omitted, focusing on factors influencing clinical course.
Molecular data (phenotype, genotype, cytogenetics) are integrated to aid diagnosis.

Conclusions:

The REAL classification provides a unified and updated framework for diagnosing lymphoid neoplasms.
Its comprehensive approach, integrating morphology, genetics, and clinical data, aims to resolve diagnostic controversies.