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Related Experiment Videos

Complement activation by angiographic catheters in vitro

K Kuroki1, S Roy, F Laerum

  • 1Institute for Surgical Research, National Hospital, University of Oslo, Norway.

Journal of Vascular and Interventional Radiology : JVIR
|September 1, 1995
PubMed
Summary
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All angiographic catheter polymers activate the complement system. Polyamide showed the most complement activation, while polyurethane showed the least, impacting medical device safety.

Area of Science:

  • Biomaterials Science
  • Immunology
  • Medical Device Engineering

Background:

  • The complement system plays a crucial role in innate immunity.
  • Angiographic catheters are essential medical devices used in cardiovascular procedures.
  • Understanding polymer interactions with the complement system is vital for improving device biocompatibility and patient outcomes.

Purpose of the Study:

  • To compare the in vitro complement activation potential of four polymers commonly used in angiographic catheters.
  • To evaluate the levels of complement activation products, specifically C3 activation products (C3AP) and the terminal complement complex (TCC), induced by these polymers.

Main Methods:

  • Commercial angiographic catheters made of polyamide, polyethylene, polyurethane, and polytetrafluoroethylene were tested.

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  • Catheter segments were incubated with fresh human serum at 37°C for up to 6 hours.
  • Enzyme immunoassays were used to quantify C3AP and TCC concentrations at various time points.

    • Main Results:

    • All tested angiographic catheter polymers significantly activated the complement system compared to controls.
    • Polyamide demonstrated the steepest increase in both C3AP and TCC concentrations over time.
    • Polyurethane exhibited the least complement activation, with marginal differences observed between polyethylene and polyurethane.

    Conclusions:

    • All polymers utilized in angiographic catheters have the potential to activate the complement system.
    • Polyamide and polyurethane represent the extremes of complement activation among the tested materials.
    • Material selection for angiographic catheters should consider their differential impact on complement activation to minimize adverse biological responses.