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Exercise- and cold-induced asthma

G G Giesbrecht1, M Younes

  • 1Faculty of Physical Education and Recreation Studies, University of Manitoba, Winnipeg.

Canadian Journal of Applied Physiology = Revue Canadienne De Physiologie Appliquee
|September 1, 1995
PubMed
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Exercise and cold trigger asthma by narrowing airways through non-antigenic means. Symptoms arise post-stimulus due to airway cooling, drying, and mediator release, with a refractory period observed.

Area of Science:

  • Respiratory Medicine
  • Exercise Physiology
  • Immunology

Background:

  • Exercise- and cold-induced asthma are common respiratory conditions.
  • Asthma involves airway narrowing due to smooth muscle contraction, mucus, vascular congestion, and epithelial damage.
  • The non-antigenic cause is linked to airway cooling and drying, leading to hypertonicity.

Purpose of the Study:

  • To elucidate the mechanisms underlying exercise- and cold-induced asthma.
  • To describe the temporal phases of the asthmatic response to these stimuli.
  • To identify factors contributing to airway narrowing and recovery.

Main Methods:

  • The study reviews existing literature on exercise- and cold-induced asthma.
  • It analyzes the physiological responses and mediator involvement.

Related Experiment Videos

  • It discusses the early and late phase responses post-stimulus.

    • Main Results:

    • Airway cooling and drying are primary triggers, leading to hypertonicity and symptoms post-stimulus.
    • Early phase responses (5-15 min) involve direct influences, vagal reflexes, or mediator release.
    • A refractory period (1-2 hrs) follows, potentially due to mediator depletion and prostaglandin inhibition.

    Conclusions:

    • Exercise and cold induce asthma through non-antigenic pathways involving airway cooling and drying.
    • The response includes early and potentially late phases, with a characteristic refractory period.
    • Understanding these mechanisms is crucial for managing exercise- and cold-induced asthma.