Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Serial circulating adhesion molecule levels reflect disease severity in systemic sclerosis

C P Denton1, M C Bickerstaff, X Shiwen

  • 1Rheumatology Research Unit, Royal Free Hospital, London.

British Journal of Rheumatology
|November 1, 1995
PubMed
Summary

Serial measurements of soluble vascular cell adhesion molecule-1 (VCAM-1) and E-selectin in systemic sclerosis (SSc) patients correlate with disease activity. These markers may serve as indicators for SSc progression or remission.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Rationale and recommendations for improving early-stage oncology diagnosis, treatment, and access.

Journal of medical economics·2026
Same author

Health-related quality of life outcomes from KEYNOTE-412: chemoradiotherapy with or without pembrolizumab in participants with head and neck squamous cell carcinoma.

Frontiers in oncology·2025
Same author

Consensus statement on the diagnosis and treatment of sclerosing diseases of the skin, Part 1: Localized scleroderma, systemic sclerosis and overlap syndromes.

Journal of the European Academy of Dermatology and Venereology : JEADV·2024
Same author

The critical need for patient-reported outcome measures to assess the severity and impact of systemic sclerosis.

The British journal of dermatology·2021
Same author

In vitro effects of macrophages on orthopaedic implant alloys and local release of metallic alloy components.

The bone & joint journal·2020
Same author

The patient knows best: a new self-reported outcome measure for systemic sclerosis.

The British journal of dermatology·2020

Area of Science:

  • Immunology
  • Rheumatology
  • Vascular Biology

Background:

  • Systemic sclerosis (SSc) involves microvascular damage and increased endothelial adhesion molecules.
  • Elevated soluble forms of intercellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1), and E-selectin have been reported in SSc.

Purpose of the Study:

  • To investigate the relationship between serial measurements of circulating ICAM-1, VCAM-1, and E-selectin and disease activity in systemic sclerosis.
  • To assess the potential of these soluble adhesion molecules as surrogate markers for SSc progression or remission.

Main Methods:

  • Collected serial serum samples from 12 SSc patients over 4-12 month intervals (mean 44 months observation).
  • Measured circulating ICAM-1, VCAM-1, and E-selectin using ELISA.

Related Experiment Videos

  • Correlated adhesion molecule levels with disease activity parameters: skin sclerosis score, serum creatinine, erythrocyte sedimentation rate, and pulmonary function tests.

    • Main Results:

    • Mean levels: ICAM-1 627 ng/ml, VCM-1 959 ng/ml, E-selectin 81 ng/ml.
    • In 88% of patients with significant disease parameter changes, VCAM-1 or E-selectin levels reflected disease severity, decreasing with improvement and increasing with deterioration.
    • A peak VCAM-1 level preceded an acute renal SSc crisis in one case; ICAM-1 levels did not correlate with clinical changes.

    Conclusions:

    • Endothelial cell dysfunction is further evidenced in systemic sclerosis.
    • Serial measurements of VCAM-1 and E-selectin show potential as valuable surrogate markers for monitoring clinical progression or remission in SSc.