Related Experiment Videos
Acute depletion of serotonin down-regulates serotonin transporter mRNA in raphe neurons
A Yu1, J Yang, A C Pawlyk
1Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia 19104, USA.
Brain Research
|August 7, 1995
Abstract:
Serotonin transporter (5-HTT) mRNA and 5-HTT sites were measured 3 days after treatment with p-chlorophenylalanine, a tryptophan hydroxylase inhibitor. While 5-HTT mRNA levels decreased (P < 0.001) in the dorsal raphe nucleus, 5-HTT binding sites remained unchanged, suggesting that an acute depletion of 5-HT may induce an increase in the turnover of 5-HTT mRNA without affecting protein levels at 3 days.