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Progressive retinal atrophy: a model for retinitis pigmentosa in companion animals
D R Sargan1, P J Clements, A Sohal
1Department of Veterinary Pathology, University of Edinburgh, Summerhall.
Gene Therapy
|January 1, 1994
Abstract:
The generalised progressive atrophies (PRA's) are a heterogeneous group of inherited retinopathies in dogs and cats. They show marked similarities to the retinitis pigmentosas (RP) in man, as well as to a number of inherited retinal degenerations of laboratory rodents. Of the various recessively inherited forms of PRA in the dog, that in the Irish setter is due to a nonsense mutation in the gene encoding cGMP-PDE-beta subunit. Mutations at this locus are also known to cause a proportion of human RP cases. We are interested in applying gene therapy to these diseases.