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Motor proteins 1: kinesins

G S Bloom1, S A Endow

  • 1Department of Cell Biology and Neuroscience, University of Texas Southwestern Medical Center, Dallas 75235, USA.

Protein Profile
|January 1, 1995
PubMed
Summary

Kinesins and related proteins are rapidly advancing, with increasing detail on their functions and properties. This review synthesizes current knowledge on these crucial motor proteins.

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Area of Science:

  • Molecular Biology
  • Cell Biology
  • Biochemistry

Background:

  • Kinesin research is accelerating, with detailed exploration of kinesin's in vivo functions and properties.
  • The kinesin superfamily now includes dozens of related proteins, with functional knowledge rapidly increasing.
  • Detailed structural information is emerging for kinesin-related proteins, such as ncd, surpassing that of kinesin heavy chain.

Purpose of the Study:

  • To provide a comprehensive review of major published works on kinesin and kinesin-related proteins.
  • To complement existing reviews and books focusing on specific aspects of the kinesin family or MT motor proteins.
  • To establish a foundation for planned annual updates on kinesin research.

Main Methods:

  • Comprehensive literature review of published works on kinesins.
  • Synthesis of data on in vivo functions, biophysical, and enzymatic properties.
  • Analysis of primary structure and functional data for kinesin-related proteins.

Main Results:

  • Significant progress in understanding kinesin and kinesin-related proteins.
  • Expanding knowledge of their structures, functions, and properties.
  • Identification of numerous kinesin-related proteins with ongoing research into their roles.

Conclusions:

  • Kinesin research is a rapidly advancing field with significant ongoing discoveries.
  • This review consolidates current knowledge and highlights the expanding understanding of kinesin functions and structures.
  • Future annual updates will track the continued progress in this dynamic area of molecular motor research.

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