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Diabetic gastroparesis

F J Farrell1, E B Keeffe

  • 1Department of Medicine, California Pacific Medical Center, San Francisco, USA.

Digestive Diseases (Basel, Switzerland)
|September 1, 1995
PubMed
Summary
This summary is machine-generated.

Diabetic gastroparesis, a common complication affecting diabetics, involves delayed gastric emptying due to autonomic neuropathy. Treatment focuses on glycemic control and prokinetic agents, with combination therapy potentially overcoming drug resistance.

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Area of Science:

  • Endocrinology
  • Gastroenterology
  • Neurology

Background:

  • Diabetic gastroparesis is a frequent complication in both type I and type II diabetes.
  • It often co-occurs with other diabetes-related complications.
  • The exact cause is unclear, but autonomic neuropathy is a significant factor.

Purpose of the Study:

  • To review the understanding of diabetic gastroparesis.
  • To outline diagnostic methods for gastric emptying.
  • To discuss current and potential treatment strategies.

Main Methods:

  • Assessment of gastric emptying using solid radiopaque markers.
  • Gastric scintigraphy to measure the rate of stomach emptying.
  • Review of existing literature on pathogenesis and treatment.

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Main Results:

  • Symptoms are nonspecific, increasing diagnostic challenges.
  • Potential complications include hypoglycemia and bezoar formation.
  • Autonomic neuropathy is implicated in the pathogenesis.

Conclusions:

  • Optimizing glycemic control is a key treatment aspect.
  • Prokinetic agents are essential for managing gastric stasis.
  • Combination or alternating prokinetic therapy may combat tachyphylaxis.