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Optimized Management of Endovascular Treatment for Acute Ischemic Stroke
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Current and future perspectives on antithrombotic therapy of acute myocardial infarction

C H Hennekens1, C J O'Donnell, P M Ridker

  • 1Brigham and Women's Hospital, Department of Medicine, Boston 02215-1204, USA.

European Heart Journal
|July 1, 1995
PubMed

Insights

Antithrombotic therapy is recommended for acute myocardial infarction. Ongoing trials will determine if aspirin alone or with anticoagulants like heparin or hirudin offers the best benefit for patients.

Area of Science:

  • Cardiology
  • Pharmacology

Background:

  • Antithrombotic therapy is standard for acute myocardial infarction.
  • Optimal antithrombotic regimen remains under investigation.

Purpose of the Study:

  • To evaluate the net benefit of different antithrombotic strategies in acute myocardial infarction.
  • To inform clinical decisions and policy guidelines.

Main Methods:

  • Analysis of ongoing randomized trials (GUSTO-2, TIMI-9) evaluating aspirin with heparin or hirudin in patients receiving thrombolytic therapy.
  • Inclusion of data from the First American Study of Infarct Survival (ASIS-1) for patients not receiving thrombolytic therapy.

Main Results:

  • Ongoing trials (GUSTO-2, TIMI-9) will provide data on aspirin plus heparin or hirudin with thrombolysis.
  • ASIS-1 will offer insights for patients not receiving thrombolytic therapy.

Conclusions:

  • Further data from ongoing trials are needed to establish optimal antithrombotic therapy for acute myocardial infarction.
  • Evidence will enable informed clinical decisions and guideline development for antithrombotic treatment.

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