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Characterization of the human XPA promoter
R S Topping1, S P Myrand, B L Williams
1Center for Molecular Medicine and Genetics, Wayne State University, Detroit, MI 48201, USA.
Gene
|December 12, 1995
Abstract:
We cloned the human xeroderma pigmentosum group A gene (XPA) and characterized the XPA promoter (pXPA) by transient cat expression. The pXPA is extraordinarily weak in human fibroblasts (1% of RSV-LTR) and appears to function without any of the usual promoter elements. Regions containing positive and negative control elements were localized.