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[A study of interleukin-6 and soluble interleukin-6 receptors during pregnancy and delivery]
1First Department of Obstetrics and Gynecology, Toho University School of Medicine, Tokyo.
In order to investigate the correlation between uterine contraction and Interleukin-6 (IL-6), we studied the effects of the prenatal course and uterine contraction on IL-6 and the soluble Interleukin-6 receptor (sIL-6R) concentration in human amniotic fluid. We also determined the effects of IL-6 on the permeability of the human amnion cell monolayer. The results were as follows: 1) The level of IL-6 at full term delivery was significantly higher than that at premature delivery. 2) The level of IL-6 without uterine contraction was significantly (p < 0.05) higher than that with uterine contraction. 3) The mean sIL-6R value at full term delivery was 1.28 +/- 0.21 ng/ml. There was no correlation between sIL-6R and the prenatal course. 4) IL-6 enhanced permeability in the human amniotic cell monolayer. This effect of Il-6 was concentration dependent and time dependent. These results show that uterine contractions increased the IL-6 concentration in human amniotic fluid, and suggest that uterine contraction enhanced the permeability of the human amniotic cell in vivo.
In order to investigate the correlation between uterine contraction and Interleukin-6 (IL-6), we studied the effects of the prenatal course and uterine contraction on IL-6 and the soluble Interleukin-6 receptor (sIL-6R) concentration in human amniotic fluid. We also determined the effects of IL-6 on the permeability of the human amnion cell monolayer. The results were as follows: 1) The level of IL-6 at full term delivery was significantly higher than that at premature delivery. 2) The level of IL-6 without uterine contraction was significantly (p < 0.05) higher than that with uterine contraction. 3) The mean sIL-6R value at full term delivery was 1.28 +/- 0.21 ng/ml. There was no correlation between sIL-6R and the prenatal course. 4) IL-6 enhanced permeability in the human amniotic cell monolayer. This effect of Il-6 was concentration dependent and time dependent. These results show that uterine contractions increased the IL-6 concentration in human amniotic fluid, and suggest that uterine contraction enhanced the permeability of the human amniotic cell in vivo.