PET hydroxyephedrine imaging of neuroblastoma
B L Shulkin1, D M Wieland, M E Baro
1Department of Internal Medicine, University of Michigan Medical Center, Ann Arbor 48109-0229, USA.
Unlabelled:
The goals of this investigation were to characterize the uptake of 11C-hydroxyephedrine (HED) in neuroblastoma and to determine the feasibility and potential advantages of utilizing this compound as a tumor imaging agent.
Methods:
Seven patients with known or subsequently proven neuroblastoma were studied. Each patient underwent PET scanning with 11C-HED. Six of seven patients underwent scintigraphy with [123I]meta-iodobenzylguanidine (MIBG), and two patients were also studied with [18F]FDG PET. For six patients, CT or MR images were available for comparison.
Results:
Neuroblastomas were located by PET scanning with 11C-HED in all seven patients. The uptake of HED into neuroblastomas was rapid; tumors were evident on images within 5 min postintravenous injection. Those lesions in the field of view of the PET camera were also identified on [123I]MIBG scintigraphic images. In two patients, tumor deposits in the abdomen were better visualized with MIBG scintigraphy due to relatively less hepatic accumulation of MIBG than HED.
Conclusion:
PET scanning with HED for neuroblastoma results in high quality functional images of the tumors that can be obtained within minutes following injection.
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