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[Changes in plasma cytokine levels during lung surgery]

T Taniguchi1, Y Matsumoto, T Yoneda

  • 1Department of Anesthesiology and Intensive Care Medicine, School of Medicine, Kanazawa University.

Masui. the Japanese Journal of Anesthesiology
|November 1, 1995
PubMed
Summary

Plasma cytokine levels, including interleukin-6 (IL-6) and interleukin-8 (IL-8), rise during lung surgery. These changes correlate with surgical stress but not severe postoperative complications in this study.

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Area of Science:

  • Immunology
  • Surgical Oncology

Context:

  • Lung surgery involves significant physiological stress.
  • Cytokines play a crucial role in the inflammatory response to surgical trauma.

Purpose:

  • To investigate the dynamic changes in plasma interleukin-6 (IL-6) and interleukin-8 (IL-8) levels during lung surgery.
  • To correlate these cytokine level changes with the degree of surgical stress and postoperative complications.

Summary:

  • Plasma levels of IL-6 and IL-8 were monitored in 20 patients undergoing lung surgery.
  • A significant increase in IL-6 and IL-8 was observed shortly after surgical incision, peaking at the end of surgery.
  • Cytokine level alterations correlated with surgical duration, blood loss, and C-reactive protein (CRP) levels for two days post-surgery.

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Impact:

  • This study highlights the rapid inflammatory response to surgical procedures.
  • Understanding cytokine dynamics can help in assessing surgical stress and potentially predicting patient outcomes.
  • No severe postoperative complications were noted, suggesting effective perioperative management despite inflammatory markers.