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Autoradiographic Measurements of [14C]-Iodoantipyrine in Rat Brain Following Central Post-Stroke Pain
Published on: July 18, 2016
The management of central post-stroke pain
1Pain Research Institute, Liverpool, UK.
Postgraduate Medical Journal
|October 1, 1995
Summary
Central post-stroke pain (CPSP) affects 2-6% of stroke survivors and is best treated with antidepressants. Early intervention with antidepressants offers the best chance for significant pain relief in CPSP patients.
Area of Science:
- Neurology
- Pain Medicine
- Stroke Rehabilitation
Background:
- Central post-stroke pain (CPSP), previously known as thalamic syndrome, can result from various brain lesions, not just thalamic.
- CPSP affects 2-6% of stroke patients, with an estimated prevalence of 20,000 in the UK, often in younger individuals with milder motor deficits.
Purpose of the Study:
- To review the characteristics, incidence, and treatment of central post-stroke pain.
- To emphasize the importance of early and appropriate medical intervention for CPSP.
Main Methods:
- Review of early post-mortem studies and modern imaging findings.
- Analysis of treatment outcomes for CPSP.
Main Results:
- Adrenergically active antidepressants are the first-line treatment for CPSP.
- Mexiletine can be added if antidepressants are ineffective. Motor cortex or spinal cord stimulation may benefit treatment-resistant cases.
- Positive relaxation therapy is a valuable adjuvant treatment, with nearly two-thirds of patients achieving considerable or total relief.
Conclusions:
- Early initiation of antidepressant treatment is crucial for optimal patient response.
- Conventional analgesics are generally ineffective for CPSP.
- Prompt and appropriate treatment can lead to significant pain reduction in a majority of CPSP patients.
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