Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Down syndrome and leukemia, an update

H A Drabkin1, P Erickson

  • 1Division of Medical Oncology, University of Colorado Cancer Center, Denver 80262, USA.

Progress in Clinical and Biological Research
|January 1, 1995
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The associations between diet quality, Body Mass Index (BMI) and Health and Activity Limitation Index (HALex) in the Geisinger Rural Aging Study (GRAS).

The journal of nutrition, health & aging·2014
Same author

Evaluation of the Brix refractometer to estimate immunoglobulin G concentration in bovine colostrum.

Journal of dairy science·2012
Same author

A phase I study of sorafenib and vorinostat in patients with advanced solid tumors with expanded cohorts in renal cell carcinoma and non-small cell lung cancer.

Investigational new drugs·2012
Same author

Visual and non-visual factors associated with patient satisfaction and quality of life in LASIK.

Eye (London, England)·2011
Same author

Pre-operative Quality of Life and psychological factors that influence patient decision making in LASIK.

Eye (London, England)·2009
Same author

HOX expression patterns identify a common signature for favorable AML.

Leukemia·2008

Acute leukemia (AL) in individuals with Down syndrome (DS) shows improved survival with modern treatments, though methotrexate poses increased toxicity. Research explores genetic links on chromosome 21 for DS-AL causes.

Area of Science:

  • Hematology
  • Genetics
  • Pediatrics

Background:

  • Acute leukemia (AL) is a rare but serious complication in Down syndrome (DS) individuals.
  • Historically associated with poorer outcomes, recent data suggests improved survival rates for DS patients with AL.
  • Understanding the unique aspects of AL in DS is crucial for advancing treatment and care.

Purpose of the Study:

  • To provide an update on advancements in understanding acute leukemia in Down syndrome.
  • To highlight changes in treatment response and toxicity in DS patients with AL.
  • To explore potential genetic factors contributing to the development of AL in individuals with DS.

Main Methods:

  • Review of recent studies and literature on acute leukemia in Down syndrome.

Related Experiment Videos

  • Analysis of treatment outcomes, including response to high-dose AraC and methotrexate toxicity.
  • Investigation of genetic associations, particularly genes on chromosome 21 implicated in leukemia.

    • Main Results:

    • DS patients with AL demonstrate comparable or superior survival rates to non-DS individuals when treated with current strategies like high-dose AraC.
    • Methotrexate exhibits increased toxicity in DS patients, necessitating careful dosage adjustments.
    • The spectrum of leukemia in DS is broader than previously thought, with various in vitro differentiation potentials.
    • Candidate genes on chromosome 21, including AML1/PEBP2alpha and ERG, are implicated in DS-associated leukemias.

    Conclusions:

    • Current treatment protocols may lead to improved outcomes for acute leukemia in Down syndrome.
    • Recognizing and managing increased methotrexate toxicity is vital for DS patients.
    • Further research into chromosome 21-related genes may elucidate the pathogenesis of DS-associated acute leukemia.