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Related Experiment Videos

Phencyclidine impairs temporal order memory for spatial locations in rats

J M Long1, R P Kesner

  • 1Department of Psychology, University of Utah, Salt Lake City 84112, USA.

Pharmacology, Biochemistry, and Behavior
|November 1, 1995
PubMed
Summary
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Phencyclidine (PCP) impairs memory for temporal-spatial order in rats, suggesting NMDA receptor involvement in hippocampal function depends on task complexity. This NMDA antagonist did not affect object discrimination.

Area of Science:

  • Neuroscience
  • Cognitive Psychology
  • Pharmacology

Background:

  • The N-methyl-D-aspartate (NMDA) receptor is crucial for synaptic plasticity and learning.
  • Hippocampal function is vital for memory, particularly for the temporal order of events.
  • Phencyclidine (PCP) is an NMDA receptor antagonist with known cognitive effects.

Purpose of the Study:

  • To investigate the effects of phencyclidine (PCP) on a hippocampus-dependent task requiring memory for temporal-spatial order.
  • To determine if PCP's effects are specific to hippocampus-dependent functions by testing it on a non-hippocampal task.

Main Methods:

  • Rats received intraperitoneal injections of saline or PCP (3-4 mg/kg).
  • Performance was assessed on a double alternation task measuring memory for the temporal order of spatial locations.

Related Experiment Videos

  • Object discrimination of three-dimensional objects was used as a control task.

    • Main Results:

    • PCP administration resulted in severe impairment on the temporal-spatial order task compared to saline controls.
    • PCP had no significant effect on the rats' ability to discriminate three-dimensional objects.
    • These findings indicate a selective impact of PCP on hippocampus-dependent memory.

    Conclusions:

    • NMDA receptor antagonism by PCP disrupts hippocampus-dependent memory for temporal-spatial sequences.
    • The hippocampus's involvement of NMDA receptors appears to be modulated by task complexity.
    • PCP's effects are specific to certain cognitive functions, highlighting the nuanced role of NMDA receptors in memory.