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Related Experiment Videos

Central 5-hydroxytryptaminergic function in irritable bowel syndrome

D A Gorard1, P A Dewsnap, S H Medbak

  • 1Dept. of Gastroenterology, St. Bartholomew's Hospital, West Smithfield, London, UK.

Scandinavian Journal of Gastroenterology
|October 1, 1995
PubMed
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Central 5-hydroxytryptaminergic pathways function normally in irritable bowel syndrome (IBS). Hormonal responses to a serotonergic challenge were similar in IBS patients and healthy controls, unlike in depression.

Area of Science:

  • Neurogastroenterology
  • Psychiatry

Background:

  • Psychological factors are implicated in irritable bowel syndrome (IBS) aetiology and symptom exacerbation.
  • Central nervous system dysfunction is suggested as a key factor in IBS.
  • Hormonal responses to serotonergic challenges assess central 5-hydroxytryptaminergic pathways, which are altered in depression.

Purpose of the Study:

  • To investigate hormonal responses in IBS patients following a serotonergic challenge.
  • To compare these responses with those in healthy volunteers and inflammatory bowel disease patients.
  • To determine if IBS exhibits decreased or exaggerated hormonal responses, as seen in depression or nonulcer dyspepsia, respectively.

Main Methods:

  • Administered 30 mg d-fenfluramine, a selective central 5-hydroxytryptaminergic pathway stimulus.

Related Experiment Videos

  • Included 14 IBS patients, 16 healthy volunteers, and 9 inflammatory bowel disease patients.
  • Measured plasma prolactin and cortisol concentrations over 5 hours post-administration.

    • Main Results:

    • Plasma prolactin and cortisol increased similarly across all groups (IBS, IBD, healthy controls).
    • IBS and IBD patients reported higher anxiety and depression scores than controls.
    • Baseline cortisol levels correlated with the severity of affective disorder.

    Conclusions:

    • Central 5-hydroxytryptaminergic pathways function normally in IBS patients.
    • Unlike depression and nonulcer dyspepsia, IBS does not show altered central 5-hydroxytryptamine receptor sensitivity.
    • Findings suggest IBS pathophysiology differs from conditions with known serotonergic pathway alterations.