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Related Experiment Videos

Association between diffuse idiopathic skeletal hyperostosis and multiple myeloma

P N Scutellari1, C Orzincolo, G Castaldi

  • 1Institute of Radiology, Ferrara University School of Medicine, Italy.

Skeletal Radiology
|October 1, 1995
PubMed
Summary

This study found a higher prevalence of diffuse idiopathic skeletal hyperostosis (DISH) in multiple myeloma patients compared to the general population. Further research is needed to understand this association.

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Area of Science:

  • Rheumatology
  • Oncology
  • Radiology

Background:

  • Diffuse idiopathic skeletal hyperostosis (DISH) is a non-inflammatory skeletal disorder.
  • Multiple myeloma is a cancer of plasma cells.

Purpose of the Study:

  • To investigate the potential association between multiple myeloma and DISH.
  • To compare the prevalence of DISH in multiple myeloma patients with control groups.

Main Methods:

  • Radiologic studies were conducted on 97 consecutive multiple myeloma patients.
  • Prevalence of DISH in patients was compared to a control group of 973 individuals and general population data.

Main Results:

  • A higher prevalence of DISH (29.8%) was observed in multiple myeloma patients compared to controls (15-20%).

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  • Specific spinal segments (thoracic, cervical, lumbar) and pelvic regions showed hyperostosis in affected patients.

    • Conclusions:

    • The coexistence of DISH and multiple myeloma may be associative, with unknown pathogenesis.
    • Further studies are required to establish the precise prevalence of DISH in the general population.