Effect of estradiol on prostaglandin metabolism in rat uterus

The purpose of this work was to investigate the effect of a single injection of estradiol (10 microng/rat) on prostaglandin(PG) metabolism in rat uterus. The PG content of uterus was increased within 6 hr after estradiol injection but the incorporation of 3H-arachidonic acid into PG in uterus was not changed within same period. The uptake of 3H-PG was increased within 6 hr after estradiol injection. In these results, it is discussed that PG from other tissue are also involved in the metabolism of PG in uterus.