Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Glomerular antigens in severe hereditary nephrosis

H Holthöfer1, A Haltia, H Jalanko

  • 1Department of Bacteriology and Immunology, University of Helsinki, Finland.

APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica
|November 1, 1995
PubMed
Summary

Congenital nephrotic syndrome of the Finnish type (CNF) involves kidney defects. Researchers found reduced alpha 2 beta 1 integrins in CNF kidneys, potentially explaining severe proteinuria.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Awareness, use and perception of patient versions of clinical practice guidelines - a national cross-sectional survey among patients with a cancer diagnosis and healthcare providers.

BMC health services research·2024
Same author

[Epidemiology and surgical treatment of pancreatic cancer in the State of Brandenburg : Analysis of 5418 cases].

Chirurgie (Heidelberg, Germany)·2022
Same author

Thoughts, beliefs and concepts concerning infectious childhood diseases of physicians practicing homeopathic, anthroposophic and conventional medicine - a qualitative study.

BMC complementary medicine and therapies·2021
Same author

Efficacy of corticosteroids in prevention of acute kidney injury in neonates undergoing cardiac surgery-A randomized controlled trial.

Acta anaesthesiologica Scandinavica·2018
Same author

Physician cooperation in outpatient cancer care. An amplified secondary analysis of qualitative interview data.

European journal of cancer care·2017
Same author

Human leucocyte antigens B*08, DRB1*03 and DRB1*13 are significantly associated with autoimmune liver and biliary diseases in Finnish children.

Acta paediatrica (Oslo, Norway : 1992)·2016

Area of Science:

  • Nephrology
  • Molecular Biology
  • Pathology

Background:

  • Congenital nephrotic syndrome of the Finnish type (CNF) is characterized by massive, treatment-resistant proteinuria.
  • The underlying cellular defect and responsible cell type in CNF remain largely unknown.

Purpose of the Study:

  • To identify the basic defect and specific glomerular cell type responsible for severe proteinuria in CNF.
  • To investigate cellular changes in kidney tissue from CNF patients using specific markers.

Main Methods:

  • Examination of CNF kidney tissue samples.
  • Utilized established antibody and lectin markers to identify glomerular endothelial, mesangial, and visceral epithelial cells.
  • Assessed qualitative changes in cell markers compared to control samples.

Related Experiment Videos

Main Results:

  • No qualitative changes were observed in glomerular or peritubular vascular endothelial cells.
  • Glomerular mesangial cells showed secondary increases in reactivity, consistent with sclerosis and mesangial expansion.
  • Visceral epithelial cell markers did not reveal significant qualitative alterations.
  • A notable reduction in alpha 2 beta 1 integrins was found across all studied CNF samples.

Conclusions:

  • The study did not identify primary defects in endothelial or visceral epithelial cells in CNF kidneys.
  • Mesangial cell changes appear secondary to the disease process.
  • The significant reduction in alpha 2 beta 1 integrins is a key finding and may be the underlying mechanism driving CNF-associated proteinuria.