[Does cholestyramine impair the bioavailability of prednisolone?]

Measurements of plasma prednisolone concentrations in two patients who received orally 37.5 and 75 mg of the drug respectively showed no differences when 8 g of cholestyramine was given with the corticosteroid. Thus, no influence of cholestyramine on the bioavailability of orally administered prednisolone could be demonstrated.