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High-performance liquid chromatographic determination of iobitridol in plasma, urine and bile
P Bourrinet1, H Feldman, A Dencausse
1Laboratoire Guerbet, Roissy Charles de Gaulle, France.
Abstract:
Iobitridol is a new non-ionic, low-osmolality contrast medium for urography and angiography. We have developed a method for determining iobitridol in body fluids using high-performance liquid chromatography with ultraviolet detection. The method, which is specific and reproducible, does not require an internal standard. Determinations can be carried out in body fluids against a set of standards in ethanol. The method was validated for the quantification of iobitridol in biological samples obtained during pharmacokinetic studies.
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