Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Complement C4, factor B and C3 polymorphism in north India

J Kramer1, L M Srivastava, E Ferenczy

  • 1National Institute of Haematology, Blood Transfusion and Immunology, Budapest, Hungary.

Acta Microbiologica Et Immunologica Hungarica
|January 1, 1995
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

OS004. A link between the complement system and angiogenic imbalance inpreeclampsia: ficolin-2 deficiency.

Pregnancy hypertension·2015
Same author

The role of the Epstein-Barr virus in the pathogenesis of some autoimmune disorders - Similarities and differences.

European journal of microbiology & immunology·2014
Same author

Serum concentration of immunoglobulin G-type antibodies against the whole Epstein-Barr nuclear antigen 1 and its aa35-58 or aa398-404 fragments in the sera of patients with systemic lupus erythematosus and multiple sclerosis.

Clinical and experimental immunology·2013
Same author

Fine-tuned characterization of RCCX copy number variants and their relationship with extended MHC haplotypes.

Genes and immunity·2012
Same author

Circulating ficolin-2 and ficolin-3 in normal pregnancy and pre-eclampsia.

Clinical and experimental immunology·2012
Same author

High anti-EBNA-1 IgG levels are associated with early-onset myasthenia gravis.

European journal of neurology·2012
Same journal

Genome-resolved analysis of multidrug-resistant ESKAPE pathogens reveals Klebsiella pneumoniae diversity and plasmid-mediated resistance in a patient in intensive care.

Acta microbiologica et immunologica Hungarica·2026
Same journal

Longitudinal effects of antiretroviral therapy on the oral microbiota in people living with HIV: A systematic review.

Acta microbiologica et immunologica Hungarica·2026
Same journal

Rare case of bacteremia, liver abscess and possible infective endocarditis caused by Fusobacterium nucleatum.

Acta microbiologica et immunologica Hungarica·2026
Same journal

New insights into Salmonella virulence: Detection of spvB and spvR genes in avian and human isolates from northeastern Algeria.

Acta microbiologica et immunologica Hungarica·2026
Same journal

Integrative analysis of the gut-liver-heart axis in coronary artery disease: From chronic metabolic dysbiosis to acute cardiogenic shock.

Acta microbiologica et immunologica Hungarica·2026
Same journal

Molecular epidemiology and prognostic impact of lower respiratory tract infections during immune checkpoint inhibitor therapy in advanced non-small cell lung cancer: A retrospective cohort study.

Acta microbiologica et immunologica Hungarica·2026
See all related articles

This study analyzed complement protein allotype frequencies in North Indians, finding C4 differences compared to Europeans. The data supports historical theories of Indian migration to Hungary.

Area of Science:

  • Immunogenetics
  • Population Genetics
  • Biochemistry

Background:

  • Complement system proteins (C4, factor B, C3) play crucial roles in immunity.
  • Understanding the genetic diversity of these proteins is vital for population genetics and evolutionary studies.
  • Previous studies have established allele frequencies in various populations, but North Indian data was lacking.

Purpose of the Study:

  • To determine the allotype frequencies of complement C4, factor B, and C3 proteins in a North Indian population.
  • To compare these frequencies with those reported in other populations, particularly European Caucasians.
  • To investigate potential genetic links between the North Indian population and Hungarian Gypsies based on complement allele frequencies.

Main Methods:

  • Blood samples were collected from 192 healthy, unrelated individuals from North India.

Related Experiment Videos

  • Protein electrophoresis and specific typing techniques were used to determine the allotypes of C4, factor B, and C3.
  • Gene frequencies were calculated based on the observed allotype distributions.

    • Main Results:

    • Gene frequencies for common factor B and C3 alleles in North Indians align with previously published data.
    • Significant differences in C4 allotype frequencies were observed between the North Indian population and European Caucasians.
    • Certain complement allele frequencies in the North Indians showed concordance with historical migration patterns linking them to Hungarian Gypsies.

    Conclusions:

    • The study provides the first comprehensive data on C4 allotype frequencies in the North Indian population.
    • The observed genetic variations in complement proteins highlight population-specific adaptations and evolutionary histories.
    • The findings support historical hypotheses regarding the Indian origin of Hungarian Gypsies, using complement protein polymorphisms as genetic markers.