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Necrotizing enterocolitis

C T Albanese1, M I Rowe

  • 1Department of Pediatric Surgery, Children's Hospital of Pittsburgh, PA 15213-2583, USA.

Seminars in Pediatric Surgery
|November 1, 1995
PubMed
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Necrotizing enterocolitis (NEC) affects vulnerable premature newborns. This article explores the hypothesis that bacteria initiate NEC in preterm infants, discussing pathology, microbiology, and clinical aspects.

Area of Science:

  • Neonatal medicine
  • Gastroenterology
  • Microbiology

Background:

  • Neonatal intensive care advances increase survival of premature infants.
  • Premature infants are at higher risk for necrotizing enterocolitis (NEC).

Purpose of the Study:

  • To present data supporting a unifying hypothesis for NEC initiation.
  • To discuss the role of bacteria as inciting agents in NEC.
  • To review NEC pathology, microbiology, clinical presentation, management, and outcomes.

Main Methods:

  • Review of existing data and literature on NEC.
  • Analysis of factors contributing to NEC in preterm infants.

Main Results:

  • Data supports a unifying hypothesis for NEC initiation.

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  • Bacteria are implicated as the inciting agents in NEC.
  • The preterm infant is identified as the vulnerable host.

    • Conclusions:

    • NEC is a complex condition in preterm infants.
    • Understanding the bacterial role is crucial for NEC prevention and management.
    • Further research is needed to fully elucidate NEC pathogenesis.