Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Antioxidant consumption during exercise in intermittent claudication

H S Khaira1, S R Maxwell, C P Shearman

  • 1Department of Surgery, Queen Elizabeth Hospital, Edgbaston, Birmingham, UK.

The British Journal of Surgery
|December 1, 1995
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Avoiding, diagnosing and treating well leg compartment syndrome after pelvic surgery.

The British journal of surgery·2019
Same author

Pharmacology and Therapeutics Education in the European Union Needs Harmonization and Modernization: A Cross-sectional Survey Among 185 Medical Schools in 27 Countries.

Clinical pharmacology and therapeutics·2017
Same author

Predicted shortage of vascular surgeons in the United Kingdom: A matter for debate?

The surgeon : journal of the Royal Colleges of Surgeons of Edinburgh and Ireland·2015
Same author

Performance of prognostic markers in the prediction of wound healing or amputation among patients with foot ulcers in diabetes: a systematic review.

Diabetes/metabolism research and reviews·2015
Same author

Effectiveness of bedside investigations to diagnose peripheral artery disease among people with diabetes mellitus: a systematic review.

Diabetes/metabolism research and reviews·2015
Same author

Effectiveness of revascularization of the ulcerated foot in patients with diabetes and peripheral artery disease: a systematic review.

Diabetes/metabolism research and reviews·2015
Same journal

Trimester-Specific Safety of Laparoscopic versus Open Abdominal Surgery During Pregnancy: A Systematic Review and Meta-analysis.

The British journal of surgery·2026
Same journal

The Gut Microbiome in Surgical Oncology: Mechanisms, Perioperative Outcomes, and Therapeutic Opportunities.

The British journal of surgery·2026
Same journal

Patient-led, home-based follow-up for colorectal cancer: the DISTANCE multicentre stepped-wedge cluster-randomised trial.

The British journal of surgery·2026
Same journal

Correction to: Reduced secretory efficiency in parathyroid carcinoma: diagnostic value of the PTH-to-tumour-volume ratio.

The British journal of surgery·2026
Same journal

Global disparities in hepatocellular carcinoma outcomes: multicentre study.

The British journal of surgery·2026
Same journal

Surgical Outcomes from Nationwide Implementation of the International Best-Practice for Locally Advanced Pancreatic Cancer (PREOPANC-4) study.

The British journal of surgery·2026
See all related articles

Peripheral artery disease patients experienced a decrease in total antioxidant concentration after exercise, alongside increased microalbuminuria, suggesting exercise-induced oxidative stress and potential ischemia-reperfusion injury.

Area of Science:

  • Biochemistry
  • Physiology
  • Medicine

Background:

  • Peripheral artery disease (PAD) is characterized by leg pain during exercise.
  • Oxidative stress and microvascular dysfunction are implicated in PAD pathophysiology.

Purpose of the Study:

  • To investigate the impact of exercise on total antioxidant concentration and microalbuminuria in patients with claudication.
  • To explore the relationship between antioxidant levels and kidney function markers post-exercise.

Main Methods:

  • Treadmill exercise test performed on 20 male claudicant patients and 9 controls.
  • Blood and urine samples collected pre- and post-exercise.
  • Total antioxidant concentration measured by enhanced chemiluminescent assay; microalbuminuria by radioimmunoassay.

Related Experiment Videos

Main Results:

  • Claudicant patients exhibited increased microalbuminuria after exercise.
  • A significant decrease in total antioxidant concentration was observed in claudicants immediately post-exercise.
  • A negative correlation was found between the reduction in antioxidant levels and the increase in microalbuminuria.

Conclusions:

  • Exercise induces a transient decrease in antioxidant capacity in claudicant patients.
  • Increased microalbuminuria post-exercise suggests kidney involvement in ischemia-reperfusion injury.
  • Findings support the role of ischemia-reperfusion injury in PAD and highlight potential therapeutic targets.