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Quantitative analysis of the olfactory pathway for drug delivery to the brain
R G Thorne1, C R Emory, T A Ala
1Department of Neurology, Ramsey Clinic/St. Paul Ramsey Medical Center, MN 55101, USA.
Brain Research
|September 18, 1995
Abstract:
Following intranasal administration to rats, wheat germ agglutinin-horseradish peroxidase (WGA-HRP) concentrated in the olfactory nerve and glomerular layers of the olfactory bulb resulting in a mean olfactory bulb concentration of 140 nM. A negligible amount of label was detected in the olfactory bulb following intravenous administration of WGA-HRP or intranasal administration of unconjugated HRP. This is the first quantitative assessment of intraneuronal transport of a protein into the brain using the olfactory route.