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[Recurrence of meningoencephalitis induced by cotrimoxazole]

F Carrillo1, A Cubero, J Hernández Gallego

  • 1Servicio de Neurología, Hospital Ntra, Sra. de Candelaria, Tenerife.

Revista De Neurologia
|January 1, 1995
PubMed

Insights

Drug-induced aseptic meningoencephalitis is rare but can occur. Trimethoprim-sulfamethoxazole caused recurrent meningoencephalitis and meningismus in a patient, presenting diagnostic challenges due to similar cerebrospinal fluid findings to bacterial meningitis.

Area of Science:

  • Neurology
  • Pharmacology
  • Infectious Diseases

Background:

  • Aseptic meningoencephalitis is an uncommon condition.
  • Drug-induced etiologies are infrequent but recognized causes.

Observation:

  • A patient experienced two episodes of meningoencephalitis and meningismus over six years.
  • These episodes were temporally associated with the consumption of trimethoprim-sulfamethoxazole (cotrimoxazole).

Findings:

  • Clinical features included mental confusion, fever, and cerebrospinal fluid (CSF) alterations.
  • The clinical course was benign, but diagnosis was challenging due to CSF anomalies mimicking partially treated bacterial meningitis.

Implications:

  • Highlights the potential for trimethoprim-sulfamethoxazole to induce aseptic meningoencephalitis.
  • Emphasizes the importance of considering drug-induced causes in recurrent meningitis presentations with atypical CSF findings.

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