Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Reversible neuropsychological deterioration associated with valproate]

J Vaquerizo1, H Gómez Martín, E González Iglesias

  • 1Departamento de Pediatría, Hospital Universitario Regional Infanta Cristina, Badajoz.

Revista De Neurologia
|January 1, 1995
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Down-regulation of heart HFABP and UCP2 gene expression in diet-induced (cafeteria) obese rats.

Journal of physiology and biochemistry·2002
Same author

[Traumatic diaphragmatic hernia of late onset].

Cirugia pediatrica : organo oficial de la Sociedad Espanola de Cirugia Pediatrica·2002
Same author

Severe phenotype in Angelman syndrome resulting from paternal isochromosome 15.

Journal of medical genetics·2002
Same author

Glutaryl-CoA dehydrogenase deficiency in Spain: evidence of two groups of patients, genetically, and biochemically distinct.

Pediatric research·2000
Same author

[Partial complex status epilepticus: diagnostic difficulties].

Revista de neurologia·1998
Same author

[State of bilateral opercular disorder and pseudobulbar paralysis of late onset in unilateral perisylvian dysplasia].

Revista de neurologia·1998

Valproate treatment for febrile convulsions can cause severe behavioral and intellectual disorders in children. Reducing the dosage led to significant improvement, highlighting potential drug-induced abnormalities.

Area of Science:

  • Pediatric Neurology
  • Neuropharmacology

Background:

  • Valproate (VPA) is a common treatment for febrile convulsions (FC).
  • While infrequent, VPA has been linked to cognitive impairments.

Observation:

  • An 8-year-old girl treated for FC developed significant behavioral and intellectual deficits.
  • Neuropsychological tests confirmed these disorders, despite therapeutic VPA plasma levels.

Findings:

  • A dose reduction of VPA resulted in rapid and dramatic clinical improvement.
  • Discontinuation of VPA led to full normalization of cognitive and behavioral functions, sustained for over a year.

Implications:

  • This case highlights rare but severe drug-induced neuropsychiatric abnormalities associated with VPA in children.

Related Experiment Videos

  • Awareness of such effects can prevent misdiagnosis and unnecessary investigations for neurodegenerative disorders.