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Updated: Sep 17, 2026

An Organotypic Slice Assay for High-Resolution Time-Lapse Imaging of Neuronal Migration in the Postnatal Brain
Published on: December 11, 2010
[Neuronal migration disorders: clinical-radiological correlation]
D Guillén1, I Pascual-Castroviejo, V López Martín
1Servicio de Neurología Pediátrica, Hospital Infantil La Paz, Madrid.
Abstract:
We present the correlation of imaging findings with clinical deficits in 34 children with several anomalies of neuronal migration which were studied retrospectively. The cases studied corresponded to: Schizencephaly 10, lissencephaly 4, heterotopy 9, and hemimegalencephaly 2. The diagnosis of the malformations was performed by computerized tomography (CT) in a few patients and by magnetic resonance (MR) in most cases. Among the clinical alterations, psychomotor delay and seizures of difficult control were the most severe, both appeared at early age. The findings observed in this study suggest the correlations between extension, location and gray matter displasticity and the neurological manifestations.

