Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Massive isotretinoin intoxication

S Aubin1, G Lorette, C Muller

  • 1Department of Dermatology, University Medical Center, Tours, France.

Clinical and Experimental Dermatology
|July 1, 1995
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[Psychiatrists who took shelter in French-speaking Switzerland from 1933-1945].

Revue medicale de la Suisse romande·1992
Same author

Systemic levels of tumor necrosis factor alpha during hemodialysis with cellulosic membranes: no effect of the sterilization procedure.

Artificial organs·1992
Same author

Quantitative assessment of urinary protein and enzyme excretion--a diagnostic programme for the detection of renal involvement in type I diabetes mellitus.

Scandinavian journal of clinical and laboratory investigation·1992
Same author

[Immunohistochemical findings in otosclerotic lesions].

HNO·1992
Same author

Peri-operative liver graft function: monitoring using the relationship between blood glucose and oxygen consumption during anaesthesia.

Anaesthesia·1992
Same author

Variables associated with the assessment of systemic tumor necrosis factor alpha levels during hemodialysis.

The International journal of artificial organs·1992
Same journal

Real-World Outcomes of Stapokibart-Based Combination Therapy for Bullous Pemphigoid: A Single-Center Retrospective Cohort.

Clinical and experimental dermatology·2026
Same journal

A second case of recessive mosaicism in ABCA12 causing a congenital unilateral epidermal nevus.

Clinical and experimental dermatology·2026
Same journal

Dermatopathology.

Clinical and experimental dermatology·2026
Same journal

Persistent Bilateral Palmar Hyperkeratotic Papules in an Adolescent Male.

Clinical and experimental dermatology·2026
Same journal

Shuddering Attacks in an Infant Treated with Atenolol for Infantile Hemangioma: A Previously Unreported Adverse Effect.

Clinical and experimental dermatology·2026
Same journal

Male genital fixed drug eruption: a systematic review.

Clinical and experimental dermatology·2026
See all related articles

A massive isotretinoin overdose (30x prescribed dose) caused mild, transient side effects like headache and skin dryness. This case highlights the low toxicity of isotretinoin overdose, with symptoms resolving spontaneously.

Area of Science:

  • Dermatology
  • Clinical Pharmacology

Background:

  • Isotretinoin is a widely used medication for severe acne.
  • Overdoses of isotretinoin are rare, with limited data on toxicity.

Observation:

  • A 29-year-old male ingested 900 mg of isotretinoin, a dose 30 times higher than prescribed.
  • The patient experienced mild headache, followed by cheilitis, cutaneous xerosis, and desquamation.
  • Serum levels of isotretinoin and its metabolite were monitored for 11 days post-ingestion.

Findings:

  • The observed side effects were mild and represented exacerbations of common isotretinoin adverse effects.
  • Cutaneous xerosis and cheilitis resolved spontaneously without specific intervention.
  • Previous reports indicate a low incidence of severe toxicity in isotretinoin overdose cases.

Related Experiment Videos

Implications:

  • Massive isotretinoin overdose appears to have low acute toxicity.
  • Clinical management should focus on monitoring and symptomatic treatment for expected side effects.
  • Further research into the pharmacokinetic and toxicodynamic profile of high-dose isotretinoin is warranted.