Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Phenylmercuric acetate intoxication in mink

G H Borst, C G Van Lieshout

    Tijdschrift Voor Diergeneeskunde
    |April 15, 1977
    PubMed
    Summary

    Phenylmercuric acetate (PMA) intoxication caused mortality in older mink, primarily affecting kidneys. Mercury levels normalized within 21 weeks, and surviving mink reproduction was unaffected.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Atypical poxvirus lesions in two Galapagos doves (Nesopelia g. galapagoensis).

    Avian pathology : journal of the W.V.P.A·2009
    Same author

    [Idiopathic gastric rupture in a Friesian foal].

    Tijdschrift voor diergeneeskunde·2004
    Same author

    Salinomycin poisoning in veal calves.

    The Veterinary record·2001
    Same author

    [Acute poisoning of pigs with hydrogen sulfide as a result of acidification of slurry on a pig farm].

    Tijdschrift voor diergeneeskunde·2001
    Same author

    Developmental anomalies in aborted and stillborn calves in The Netherlands.

    The Veterinary record·2000
    Same author

    [Mastitis following drying up associated with teat wipes contaminated with Pseudomonas aeruginosa].

    Tijdschrift voor diergeneeskunde·1998

    Area of Science:

    • Toxicology
    • Veterinary Pathology
    • Environmental Health

    Background:

    • Phenylmercuric acetate (PMA) is a mercury-containing compound with known toxic properties.
    • Accidental intoxications can occur, necessitating an understanding of its effects on animal health and environmental persistence.

    Purpose of the Study:

    • To investigate the pathological effects and mercury residue dynamics following incidental phenylmercuric acetate (PMA) intoxication in mink.
    • To assess the impact of PMA exposure on mink mortality, organ damage, mercury clearance, and reproductive capacity.

    Main Methods:

    • Mink were exposed to phenylmercuric acetate (PMA).
    • Mortality rates, clinical signs, and gross pathology were recorded.
    • Kidney histopathology was performed to identify tubulonephrosis.
    • Mercury levels in various organs and tissues were quantified over time.
    • Reproductive success of surviving animals was evaluated.

    Main Results:

    • Mortality occurred predominantly in older mink (31% females, 40% males).
    • Kidneys exhibited severe tubulonephrosis and the highest mercury concentrations.
    • No central nervous system lesions were observed.
    • Mercury residues returned to normal levels within 21 weeks post-exposure.
    • Mercury half-lives varied by organ, with skeletal muscle being the fastest (10 days) and liver the slowest (36 days).
    • Reproductive capacity of surviving mink remained unaffected.

    Conclusions:

    • Phenylmercuric acetate (PMA) poses a significant risk to mink health, particularly affecting older individuals and causing severe kidney damage.
    • The body effectively eliminates mercury over time, with organ-specific clearance rates.
    • Despite acute intoxication effects, long-term reproductive function in surviving mink is not compromised by PMA exposure.

    Related Experiment Videos