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Quinolones and osteomyelitis: state-of-the-art
1Division of Infectious Disease, Geneva University Hospital, Switzerland.
Drugs
|January 1, 1995
Summary
Quinolones show over 90% success in treating Enterobacteriaceae osteomyelitis with oral ciprofloxacin. More research is needed for Staphylococcus aureus, Pseudomonas aeruginosa, diabetic, and foreign body infections.
Area of Science:
- Pharmacology
- Infectious Diseases
- Orthopedic Surgery
Background:
- Osteomyelitis is a serious bone infection.
- Quinolones are a class of antibiotics with potential applications in treating bone infections.
- Understanding quinolone efficacy and bone penetration is crucial for effective treatment.
Purpose of the Study:
- To critically analyze the quantitative use of quinolones in osteomyelitis.
- To evaluate quinolone penetration into human bone tissue.
- To assess the clinical effectiveness of quinolones in various osteomyelitis scenarios.
Main Methods:
- Systematic review of peer-reviewed literature.
- Inclusion of studies on experimental osteomyelitis.
- Analysis of quinolone bone penetration and clinical trial data (comparative and non-comparative).
Main Results:
- Oral ciprofloxacin demonstrated over 90% clinical success rates for Enterobacteriaceae-related osteomyelitis with prolonged use.
- Quinolones show promising results in specific osteomyelitis cases.
Conclusions:
- Oral quinolones, particularly ciprofloxacin, are highly effective for Enterobacteriaceae osteomyelitis.
- Further comparative studies are necessary for Staphylococcus aureus and Pseudomonas aeruginosa osteomyelitis.
- Additional research is required for complex cases like diabetic osteomyelitis and foreign body infections.