Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Fluoroquinolone toxicities. An update

P S Lietman1

  • 1Division of Clinical Pharmacology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.

Drugs
|January 1, 1995
PubMed
Summary

Quinolone antibiotics have uncommon, reversible side effects like phototoxicity and neurotoxicity. Post-marketing surveillance is crucial, but fluoroquinolones remain effective and well-tolerated antimicrobial drugs.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Ex vivo zidovudine (AZT) treatment of CD34+ bone marrow progenitors causes decreased steady state mitochondrial DNA (mtDNA) and increased lactate production.

Human & experimental toxicology·2004
Same author

Phase i/ii trial of the pharmacokinetics, safety, and antiretroviral activity of tenofovir disoproxil fumarate in human immunodeficiency virus-infected adults.

Antimicrobial agents and chemotherapy·2001
Same author

Clinical pharmacokinetics of 1-[((S)-2-hydroxy-2-oxo-1,4,2-dioxaphosphorinan-5-yl)methyl]cytosine in human immunodeficiency virus-infected patients.

Antimicrobial agents and chemotherapy·1999
Same author

The effect of increasing gastric pH upon the bioavailability of orally-administered foscarnet.

Antiviral research·1998
Same author

Safety, pharmacokinetics, and antiretroviral activity of intravenous 9-[2-(R)-(Phosphonomethoxy)propyl]adenine, a novel anti-human immunodeficiency virus (HIV) therapy, in HIV-infected adults.

Antimicrobial agents and chemotherapy·1998
Same author

Two doses of PMPA protect newborn macaques against oral simian immunodeficiency virus infection.

AIDS (London, England)·1998

Area of Science:

  • Pharmacology
  • Microbiology
  • Drug Safety

Background:

  • Quinolones are a class of antimicrobial drugs.
  • Adverse effects associated with quinolone use are generally uncommon and reversible.
  • Variability in adverse effect frequency exists among different quinolone agents.

Purpose of the Study:

  • To review the adverse effects of quinolone antimicrobial drugs.
  • To highlight specific adverse events such as phototoxicity, neurotoxicity, and arthropathy.
  • To emphasize the importance of post-marketing surveillance for quinolone safety.

Main Methods:

  • Literature review of quinolone adverse effects.
  • Analysis of reported side effects including phototoxicity, neurotoxicity, and arthropathy.
  • Consideration of clinical experience and drug withdrawal data.

Main Results:

  • Phototoxicity is more frequent with lomefloxacin compared to other quinolones.
  • Neurotoxic effects may involve rare proconvulsant activity.
  • Arthropathy presents a challenge for pediatric use.
  • The withdrawal of temafloxacin underscores the need for surveillance.

Conclusions:

  • Quinolones, as a group, are effective and well-tolerated antimicrobial agents.
  • While adverse effects are uncommon, specific toxicities require monitoring.
  • Post-marketing surveillance is essential for ensuring the safe use of quinolones.

Related Experiment Videos