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Structure-activity relationships of some 4-quinazolylthiosemicarbazides and their triazolo derivatives
S Jantová1, D Hudecová, K Spirková
1Department of Microbiology, Biochemistry and Biology, Faculty of Chemical Technology, Slovak Technical University, Bratislava, Slovakia.
Folia Microbiologica
|January 1, 1994
Abstract:
Eight 4-quinazolylthiosemicarbazides and nine of their structural analogues have been tested for antibacterial effects and for structure activity relationships. 9-Chloro-5-morpholino-1,2,4-triazolo[4,3-c]quinazoline-3-thione has demonstrated the highest antibacterial effect (MIC of 1 mg/L for E. coli and P. mirabilis and < 1 mg/L for S. aureus and B. subtilis). The most effective derivatives have the carbon aromatic ring substituted with chlorine and the pyrimidine ring with morpholine or with secondary amine group.