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Assessing the efficacy of a mixed vaccination strategy against rubella in São Paulo, Brazil
E Massad1, R S Azevedo-Neto, M N Burattini
1Faculdade de Medicina da Universidade de São Paulo, Brazil.
Insights
Brazil
Area of Science:
- Public Health
- Epidemiology
- Vaccinology
Background:
- A significant measles-mumps-rubella vaccination strategy was implemented in São Paulo, Brazil, in 1992.
- This strategy combined a pulse vaccination for children aged 1-10 years with routine vaccination at 15 months.
Purpose of the Study:
- To evaluate the effectiveness of this combined measles-mumps-rubella vaccination strategy.
- To assess the impact on rubella seroprevalence and congenital rubella syndrome (CRS) incidence.
Main Methods:
- A rubella seroprevalence survey was conducted among 4953 children aged 1-15 years.
- Data collection occurred immediately and one year post-vaccination campaign.
Main Results:
- Rubella seroprevalence significantly increased from 0.40 to 0.97.
- A dramatic reduction in reported congenital rubella syndrome (CRS) cases was observed.
Conclusions:
- The mixed vaccination strategy for rubella proved highly effective in São Paulo.
- This approach significantly reduced the incidence of congenital rubella syndrome (CRS).
Background:
In 1992 a major vaccination strategy against measles-mumps-rubella was introduced in the State of Saão Paulo, Brazil. This strategy was based on mathematical models and comprised a pulse vaccination covering all children aged 1-10 years, followed by the inclusion of this vaccine in the routine calendar at 15 months of age. The present work reports the evaluation of the efficacy of this mixed vaccination strategy.
Methods:
A rubella seroprevalence survey was carried out immediately and one year after the campaign, comprising 4953 children aged 1-15 years.
Results:
We show that average rubella seroprevalence increased from 0.40 to 0.97 and that the reported number of congenital rubella syndrome (CRS) cases dropped dramatically.
Conclusions:
The mixed vaccination strategy adopted against rubella has proved to be very effective in reducing the number of CRS cases in São Paulo.