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Frur mediates catabolite activation of pyruvate kinase (pykF) gene expression in Escherichia coli
S A Bledig1, T M Ramseier, M H Saier
1Department of Biology, University of California at San Diego, La Jolla 92093-0116, USA.
Journal of Bacteriology
|January 1, 1996
Abstract:
Expression of a pykF-lacZ fusion was studied as a function of the carbon source in wild-type strains and strains lacking or overproducing the FruR protein of Escherichia coli. FruR controls the response to the carbon source by repressing pykF expression more strongly under gluconeogenic than under glycolytic conditions, a phenomenon we term catabolite activation.