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Related Experiment Videos

Genetic influence on bone turnover in postmenopausal twins

P Garnero1, N K Arden, G Griffiths

  • 1INSERM U-403, Hôpital E. Herriot, Lyon, France.

The Journal of Clinical Endocrinology and Metabolism
|January 1, 1996
PubMed
Summary

Genetic factors influence postmenopausal bone turnover, particularly for markers not significantly altered by menopause. This suggests a small role for genetics in overall postmenopausal bone loss.

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Area of Science:

  • Endocrinology
  • Genetics
  • Osteoporosis Research

Background:

  • Peak bone mass is influenced by genetics, affecting bone formation.
  • Postmenopausal bone loss rate varies significantly among individuals.
  • Understanding genetic control of postmenopausal bone turnover is crucial for explaining bone loss variability.

Purpose of the Study:

  • To investigate the genetic control of postmenopausal bone turnover.
  • To link genetic factors to the rate of postmenopausal bone loss.
  • To assess the heritability of bone formation and resorption markers.

Main Methods:

  • Classical twin study comparing monozygotic (MZ) and dizygotic (DZ) twins.
  • Measurement of bone formation markers (osteocalcin, bone-specific alkaline phosphatase, propeptide of type I collagen).

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  • Measurement of bone resorption markers (deoxypyridinoline, CrossLaps, NTX).

    • Main Results:

    • Higher intraclass correlations for bone formation markers in MZ vs. DZ twins, significant for bone-specific alkaline phosphatase.
    • Significant genetic influence on serum propeptide of type I collagen variance (rMZ=0.82, rDZ=0.33).
    • Significant genetic influence on urinary free deoxypyridinoline variance (P=0.002), and borderline for NTX (P=0.03).

    Conclusions:

    • Genetic factors explain a proportion of variance in postmenopausal bone turnover markers.
    • Genetic contribution is significant for markers not markedly changing at menopause.
    • The overall contribution of genetic factors to postmenopausal bone turnover and loss appears small.