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Related Experiment Videos

[Hand-mirror cells acute lymphoblastic leukemia (L3)]

K Uemura1, H Otani, K Sakamoto

  • 1Central Clinical Laboratory, University of Occupational and Environmental Health, Kitakyusyu.

Rinsho Byori. the Japanese Journal of Clinical Pathology
|November 1, 1995
PubMed
Summary

This report details the first documented case in Japan of a 15-year-old boy diagnosed with acute lymphoblastic leukemia (ALL). The specific subtype, L3, featured distinctive hand-mirror cells (HMC) in his bone marrow.

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Area of Science:

  • Hematology
  • Oncology
  • Pediatric Medicine

Background:

  • Acute lymphoblastic leukemia (ALL) is a significant hematologic malignancy.
  • Hand-mirror cell (HMC) morphology is a rare feature observed in certain leukemias and lymphomas.

Observation:

  • This case presents the first confirmed instance in Japan of a 15-year-old male with ALL L3 subtype.
  • The patient's bone marrow exhibited lymphoblasts with characteristic hand-mirror cell morphology.

Findings:

  • HMC lymphoblasts are defined by an asymmetric, foot-like cytoplasmic projection.
  • While HMC morphology is noted in various hematologic conditions, it is less commonly associated with the ALL L3 subtype compared to L1 and L2.

Implications:

Related Experiment Videos

  • This case expands the geographic and demographic understanding of HMC lymphoid leukemia.
  • Highlights the importance of recognizing rare morphologic variants in diagnosing and managing ALL.