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Ethanol-induced single-strand DNA breaks in rat brain cells
1Department of Psychiatry & Behavioral Sciences, School of Medicine, University of Washington, Seattle 98195-6560, USA. narendra@u. washington.edu
Mutation Research
|December 1, 1995
Abstract:
Male Sprague-Dawley rats were intubated with 4 g/kg body weight of ethanol (in a 20%, v/v, water solution). Brain cells were analyzed for single-strand DNA breaks at various post-ethanol administration time points using an alkaline microgel electrophoresis assay. Results showed a significant increase in single-strand DNA breaks in brain cells that peaked at approx. 4 h and returned to control level within 6 h after ethanol administration.