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Updated: Jul 28, 2026

G Protein-selective GPCR Conformations Measured Using FRET Sensors in a Live Cell Suspension Fluorometer Assay
09:12

G Protein-selective GPCR Conformations Measured Using FRET Sensors in a Live Cell Suspension Fluorometer Assay

Published on: September 10, 2016

The 2.0 A crystal structure of a heterotrimeric G protein

D G Lambright1, J Sondek, A Bohm

  • 1Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut 06510, USA.

Nature
|January 25, 1996
PubMed

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G-protein coupled receptors are ligand binding receptors that indirectly affect changes in the cell. The actual receptor is a single polypeptide that transverses the cell membrane seven times creating intracellular and extracellular loops. The extracellular loops create a ligand specific pocket which binds to neurotransmitters or hormones. The intracellular loops holds onto the G-protein.
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