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Choline substitution for sodium triggers glutamate and adenosine release from rat hippocampal slices
1Department of Physiology, Texas Tech University Health Sciences Center, Lubbock 79430, USA.
Neuroscience Letters
|September 8, 1995
Abstract:
Substituting choline for sodium resulted in an extracellularly recorded transient depolarization and increased efflux of glutamate and adenosine from rat hippocampal slices. The depolarization was blocked by a combination of NMDA and non-NMDA antagonists, MK-801 (10 microM) and 6,7-dinitroquinoxaline-2,3-dione (DNQX, 50 microM). Adenosine release was blocked by MK-801 alone. These data suggest that glutamate released as a result of the sodium removal acts at NMDA and non-NMDA glutamate receptors to trigger the depolarization and acts at NMDA receptors to trigger adenosine release.